– Causes are

1) Genetic Susciptibility:

•  Individuals with HLA-DRB/*402, 1401/04 , DAB/*503 are susceptible to develop PV 
• Chase with DRB/*0102, 0404 are susceptible to develop PF

2) Ethnic Groups :

• Jeues are more commonly affected than non-jeues. In India demo Gujrat and Assam are more vulnerable to develop disease.

3) 1st degree relatives of Pemphigus patients 

4) Environmental Factors: 

• Sunlight exposure ueoesens the disease 
• Exposure to pesticides, goods that contain thials, phenols and polyphenolic compounds like tannis
• consumption of goods containing thiols like garlic and onion.

5) Immunology

• Autoantibodies are directed against antigens located in epidermis(Desmosomes)
• Desmosomes are disreupted cells become rounded and seprate.