1.What is Pemphigus Vulgaris ?
Pemphigus Vulgaris is a rare autoimmune disease that causes painful blistering on the skin and mucous membranes.
2. How this name was given ?
Pemphigus is derived from the Greek word pemphix, meaning blister.
3. What is Autoimmune Disease ?
An autoimmune disorder occurs when the body’s immune system attacks and destroys healthy body tissue by mistake. There are more than 80 types of autoimmune disorders.
4. What happens in Autoimmune Disease ?
In response to an unknown trigger, the immune system may begin producing antibodies that instead of fighting infections, attack the body’s own tissues
5. Details of skin
The skin is the largest organ in the human body, representing 16% of the total body weight.
6. Which part of skin is affected ?
The epidermis is comprised of the following five layers BRIDGE LIKE structures called the hemidesmosome. in autoimmune bullous skin. The lesions are induced by the presence of autoantibodies against proteins in the desmosomes, which are the attachment structures of keratinocytes.
7. What is meaning of Pemphigus ?
Pemphigus (in Greek, pemphix means blister) is a group of blistering diseases with an organ-specific autoimmune pathogenesis that affects the skin and mucous membranes.
8. What happens to skin in Pemphigus Vulgaris ?
The clinical hallmark of this group of diseases is the presence of intraepidermal bullae; the lesion can be produced artificially by pressing the skin between two fingers and the positive Nikolsky sign consisting of the detachment of the surface layers of the skin.Blisters goes on increasing in size.
9. Incidence of Pemphigus ?
Pemphigus has a worldwide distribution, with an incidence of 0.1 to 0.5/100,000 and occurs more often in women (1.5:1) between the fourth and fifth decade of life . In addition to the disease in humans, this disease is also observed in horses, dogs, and cats.
10. Who gets Phemphigus ?
Some genetic combination pepole develop Pemphigus DRB1*1404 is the most important risk factor in an Indo-Asian population.
11. How many have oral mucosa involved ?
The oral mucosa is affected primarily in approximately 70% of cases, causing dysphagia for months.
12. What happens if we don’t see a doctor ?
Blisters can erupt and leave erosions and crusts, and if the lesions are extensive, then electrolyte abnormalities, fluid loss, and hypoproteinemia may be observed.
13. How do we know we have Phemphigus ?
One may have oral ulcer not healing for long time, blisters on skin,scalp like burns,may have pain in skin.
14. Common problems seen ?
The most common complication of this disease is secondary infection.
15. What happens if we don’t take treatment ?
Blisters may cover full body.smell bad.Have infection.Cannot wear cloths.Oral Ulcer will not be able to Eat.Low Blood Pressure Emergency
16. How to keep skin clean ?
Buy normal Saline 500 ML Bottle OR 1 Liter Warm Water Add Spoon of Salt allow it to Dissolve. Take clean cotton Muslin,Thin Cloth .OR old Cotton Dhoti OR Saree. Dip in Salt Water Fold it keep over Ulcers,Blisters for 10 MIN.Repeat it 3 to 5 time
17. How to take care of mouth if Ulcers are there ?
Use Soft Brush.Gargle 3 times with Salt Water or Chlorhexidine Mouth Wash